Drug interactions
Carbidopa-entacapone-levodopa + Timolol
Severity: Moderate
Carbidopa-entacapone-levodopa and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa-containing products can cause orthostatic hypotension, and systemic timolol, a beta-blocker, lowers blood pressure and heart rate. Together they may produce additive hypotension, particularly at initiation or after dose changes. Systemic absorption from ophthalmic timolol can also be relevant.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from levodopa-related vasodilation and autonomic effects with beta-adrenergic blockade.
What to do
Monitor blood pressure including standing readings when starting or changing doses, and lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Timolol?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa-containing products can cause orthostatic hypotension, and systemic timolol, a beta-blocker, lowers blood pressure and heart rate. Together they may produce additive hypotension, particularly at initiation or after dose changes. Systemic absorption from ophthalmic timolol can also be relevant.
How serious is the interaction between Carbidopa-entacapone-levodopa and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings when starting or changing doses, and lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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