Drug interactions
Carbidopa-entacapone-levodopa + Trandolapril
Severity: Moderate
Carbidopa-entacapone-levodopa and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa may cause postural hypotension, and the ACE inhibitor trandolapril lowers blood pressure. The combination can produce additive hypotension, most noticeable at therapy initiation.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through dopaminergic vasodilation and inhibition of the renin-angiotensin system.
What to do
Monitor blood pressure, including standing values, when either drug is started or titrated, and reduce the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbidopa-entacapone-levodopa and Trandolapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Trandolapril?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa may cause postural hypotension, and the ACE inhibitor trandolapril lowers blood pressure. The combination can produce additive hypotension, most noticeable at therapy initiation.
How serious is the interaction between Carbidopa-entacapone-levodopa and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing values, when either drug is started or titrated, and reduce the antihypertensive dose if symptomatic.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
