Drug interactions
Carbidopa-entacapone-levodopa + Valsartan
Severity: Moderate
Carbidopa-entacapone-levodopa and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa may cause postural hypotension and valsartan lowers blood pressure through angiotensin receptor blockade. Combined use can lead to additive hypotension, especially at initiation or with dose increases.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Valsartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from dopaminergic effects and angiotensin II receptor blockade.
What to do
Monitor blood pressure including standing readings when starting or adjusting either drug, and lower the valsartan dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Valsartan?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa may cause postural hypotension and valsartan lowers blood pressure through angiotensin receptor blockade. Combined use can lead to additive hypotension, especially at initiation or with dose increases.
How serious is the interaction between Carbidopa-entacapone-levodopa and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings when starting or adjusting either drug, and lower the valsartan dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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