Drug interactions
Carbidopa-entacapone-levodopa + Zuranolone
Severity: Moderate
Carbidopa-entacapone-levodopa and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked sedation and impairs psychomotor performance and driving ability. Levodopa and entacapone can also cause somnolence and sudden sleep onset, so the combined effect may increase impairment.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression through the GABA-A positive modulation of zuranolone and the sedative effects of dopaminergic therapy.
What to do
Consider reducing the zuranolone dose if excessive sedation occurs, and counsel patients not to drive or operate machinery. Monitor for somnolence and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Zuranolone?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes marked sedation and impairs psychomotor performance and driving ability. Levodopa and entacapone can also cause somnolence and sudden sleep onset, so the combined effect may increase impairment.
How serious is the interaction between Carbidopa-entacapone-levodopa and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if excessive sedation occurs, and counsel patients not to drive or operate machinery. Monitor for somnolence and falls.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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