Drug interactions
Amobarbital + Zuranolone
Severity: Major
Amobarbital and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so combined use increases sedation and psychomotor impairment. Amobarbital may also reduce zuranolone levels through CYP3A4 induction, which may weaken antidepressant effect.
What this interaction means in plain words
Amobarbital and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP3A4 induction by amobarbital increasing zuranolone metabolism.
What to do
Avoid the combination where possible. If used together, monitor sedation and treatment response and warn against driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Zuranolone
Frequently asked questions
Can I take Amobarbital with Zuranolone?
MediHelp rates the interaction as major. Amobarbital and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, so combined use increases sedation and psychomotor impairment. Amobarbital may also reduce zuranolone levels through CYP3A4 induction, which may weaken antidepressant effect.
How serious is the interaction between Amobarbital and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor sedation and treatment response and warn against driving.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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