Drug interactions
Carbidopa-levodopa + Carvedilol
Severity: Moderate
Carbidopa-levodopa and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa may cause orthostatic hypotension, and carvedilol with its alpha-blocking activity adds substantially to this effect. Dizziness, falls and syncope can result, especially early in therapy.
What this interaction means in plain words
Carbidopa-levodopa and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Carvedilol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of levodopa and combined alpha and beta blockade.
What to do
Monitor orthostatic blood pressure when either drug is started or titrated. Reduce the carvedilol dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carbidopa-levodopa with Carvedilol?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa may cause orthostatic hypotension, and carvedilol with its alpha-blocking activity adds substantially to this effect. Dizziness, falls and syncope can result, especially early in therapy.
How serious is the interaction between Carbidopa-levodopa and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when either drug is started or titrated. Reduce the carvedilol dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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