Drug interactions
Carbidopa-levodopa + Fenoldopam
Severity: Moderate
Carbidopa-levodopa and Fenoldopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a dopamine D1 agonist and vasodilator used for severe hypertension. Levodopa-derived dopamine and its hypotensive tendency may add to this effect and cause excess blood pressure reduction.
What this interaction means in plain words
Carbidopa-levodopa and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopaminergic vasodilation and hypotensive effects.
What to do
Monitor blood pressure frequently during fenoldopam infusion and titrate to effect, with lower doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Frequently asked questions
Can I take Carbidopa-levodopa with Fenoldopam?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a dopamine D1 agonist and vasodilator used for severe hypertension. Levodopa-derived dopamine and its hypotensive tendency may add to this effect and cause excess blood pressure reduction.
How serious is the interaction between Carbidopa-levodopa and Fenoldopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure frequently during fenoldopam infusion and titrate to effect, with lower doses if hypotension develops.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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