Drug interactions
Carbidopa-levodopa + Midazolam intranasal
Severity: Moderate
Carbidopa-levodopa and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a benzodiazepine causing sedation and respiratory depression, and levodopa may add somnolence. Benzodiazepines may also reduce the antiparkinsonian effect of levodopa in some patients.
What this interaction means in plain words
Carbidopa-levodopa and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; possible benzodiazepine antagonism of dopaminergic effect.
What to do
Monitor sedation and respiratory status after dosing and watch for worsening parkinsonian symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Frequently asked questions
Can I take Carbidopa-levodopa with Midazolam intranasal?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a benzodiazepine causing sedation and respiratory depression, and levodopa may add somnolence. Benzodiazepines may also reduce the antiparkinsonian effect of levodopa in some patients.
How serious is the interaction between Carbidopa-levodopa and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after dosing and watch for worsening parkinsonian symptoms.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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