Drug interactions
Carbonyl iron + Fleroxacin
Severity: Moderate
Carbonyl iron and Fleroxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron binds fluoroquinolones such as fleroxacin in the gut, markedly reducing their absorption. This may result in subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Carbonyl iron and Fleroxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of the fluoroquinolone by iron in the gastrointestinal tract reduces absorption.
What to do
Give fleroxacin at least 2 hours before or several hours after the iron dose. Consider an alternative anti-infective if dosing cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Fleroxacin?
MediHelp rates the interaction as moderate. Carbonyl iron and Fleroxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron binds fluoroquinolones such as fleroxacin in the gut, markedly reducing their absorption. This may result in subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Carbonyl iron and Fleroxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fleroxacin at least 2 hours before or several hours after the iron dose. Consider an alternative anti-infective if dosing cannot be separated.
What other medicines interact with Carbonyl iron?
MediHelp also lists interactions of Carbonyl iron with, for example, Aluminum hydroxide, Baloxavir marboxil, Calcium acetate. The full list is on the Carbonyl iron page.
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