Drug interactions
Carbonyl iron + Lansoprazole
Severity: Moderate
Carbonyl iron and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron needs gastric acid for dissolution and absorption, so a PPI such as lansoprazole can reduce iron uptake. Prolonged use can contribute to iron deficiency or poor response to iron therapy.
What this interaction means in plain words
Carbonyl iron and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acidity impairs dissolution and conversion of iron to an absorbable form.
What to do
Monitor hemoglobin and ferritin, and consider a higher iron dose, alternate-day dosing, or IV iron if response is poor. Review the need for continued PPI therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Lansoprazole?
MediHelp rates the interaction as moderate. Carbonyl iron and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron needs gastric acid for dissolution and absorption, so a PPI such as lansoprazole can reduce iron uptake. Prolonged use can contribute to iron deficiency or poor response to iron therapy.
How serious is the interaction between Carbonyl iron and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin, and consider a higher iron dose, alternate-day dosing, or IV iron if response is poor. Review the need for continued PPI therapy.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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