Drug interactions
Carbonyl iron + Rabeprazole
Severity: Moderate
Carbonyl iron and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acid from rabeprazole impairs absorption of oral non-heme iron, particularly with carbonyl iron which needs acid for dissolution. Prolonged use can contribute to iron deficiency or poor response to iron therapy.
What this interaction means in plain words
Carbonyl iron and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces dissolution and reduction of ferric iron to the absorbable ferrous form.
What to do
Monitor hemoglobin and ferritin; consider a lower PPI dose or parenteral iron if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Rabeprazole?
MediHelp rates the interaction as moderate. Carbonyl iron and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reduced gastric acid from rabeprazole impairs absorption of oral non-heme iron, particularly with carbonyl iron which needs acid for dissolution. Prolonged use can contribute to iron deficiency or poor response to iron therapy.
How serious is the interaction between Carbonyl iron and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin; consider a lower PPI dose or parenteral iron if response is inadequate.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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