Drug interactions
Carboplatin + Cyclosporin
Severity: Moderate
Carboplatin and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can damage the kidneys, and carboplatin may cause ototoxicity at high doses. Together they may increase the risk of renal impairment and reduced clearance of carboplatin.
What this interaction means in plain words
Carboplatin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from cyclosporine-induced renal vasoconstriction and carboplatin tubular injury.
What to do
Monitor serum creatinine and electrolytes, adjust carboplatin dose to renal function, and check cyclosporine levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Cyclosporin?
MediHelp rates the interaction as moderate. Carboplatin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can damage the kidneys, and carboplatin may cause ototoxicity at high doses. Together they may increase the risk of renal impairment and reduced clearance of carboplatin.
How serious is the interaction between Carboplatin and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes, adjust carboplatin dose to renal function, and check cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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