Drug interactions
Carboplatin + Foscarnet
Severity: Moderate
Carboplatin and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet is notably nephrotoxic and causes electrolyte disturbances, while carboplatin can also impair renal function and, less commonly, hearing. Together they increase the risk of kidney injury and carboplatin accumulation, since carboplatin is renally cleared.
What this interaction means in plain words
Carboplatin and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Foscarnet belongs to Anti Virals.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of carboplatin when kidney function declines.
What to do
Monitor serum creatinine, electrolytes (calcium, magnesium, potassium, phosphate) and hydration status. Adjust foscarnet and carboplatin doses to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Foscarnet?
MediHelp rates the interaction as moderate. Carboplatin and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet is notably nephrotoxic and causes electrolyte disturbances, while carboplatin can also impair renal function and, less commonly, hearing. Together they increase the risk of kidney injury and carboplatin accumulation, since carboplatin is renally cleared.
How serious is the interaction between Carboplatin and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes (calcium, magnesium, potassium, phosphate) and hydration status. Adjust foscarnet and carboplatin doses to renal function.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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