Drug interactions
Carboplatin + Ifosfamide
Severity: Moderate
Carboplatin and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress bone marrow function, so combination regimens carry a higher risk of neutropenia and thrombocytopenia. Overlapping renal toxicity is also possible.
What this interaction means in plain words
Carboplatin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Additive myelosuppression, with overlapping nephrotoxicity.
What to do
Monitor blood counts and renal function before each cycle and adjust doses or delay treatment as needed. Provide supportive care such as growth factors when indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Ifosfamide?
MediHelp rates the interaction as moderate. Carboplatin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress bone marrow function, so combination regimens carry a higher risk of neutropenia and thrombocytopenia. Overlapping renal toxicity is also possible.
How serious is the interaction between Carboplatin and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function before each cycle and adjust doses or delay treatment as needed. Provide supportive care such as growth factors when indicated.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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