Drug interactions
Carboplatin + Streptomycin
Severity: Major
Carboplatin and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carboplatin can cause ototoxicity and nephrotoxicity, and combining it with an aminoglycoside raises the risk of hearing loss and kidney injury. These effects may be irreversible.
What this interaction means in plain words
Carboplatin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic and ototoxic effects.
What to do
Avoid combination where possible. If needed, monitor renal function and hearing with baseline and serial audiometry.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Streptomycin?
MediHelp rates the interaction as major. Carboplatin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carboplatin can cause ototoxicity and nephrotoxicity, and combining it with an aminoglycoside raises the risk of hearing loss and kidney injury. These effects may be irreversible.
How serious is the interaction between Carboplatin and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible. If needed, monitor renal function and hearing with baseline and serial audiometry.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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