Drug interactions
Carboplatin + Tobramycin
Severity: Moderate
Carboplatin and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can damage the kidneys and inner ear, and combined use increases the risk of renal impairment and hearing loss. Carboplatin is less nephrotoxic than cisplatin, but ototoxicity and renal effects can still be additive.
What this interaction means in plain words
Carboplatin and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Tobramycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic and ototoxic effects of platinum compounds and aminoglycosides.
What to do
Monitor serum creatinine, electrolytes and tobramycin levels, and consider audiometry for prolonged use. Adjust carboplatin dosing to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Tobramycin?
MediHelp rates the interaction as moderate. Carboplatin and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can damage the kidneys and inner ear, and combined use increases the risk of renal impairment and hearing loss. Carboplatin is less nephrotoxic than cisplatin, but ototoxicity and renal effects can still be additive.
How serious is the interaction between Carboplatin and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and tobramycin levels, and consider audiometry for prolonged use. Adjust carboplatin dosing to renal function.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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