Drug interactions
Carboplatin + Trastuzumab
Severity: Moderate
Carboplatin and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab combined with myelosuppressive chemotherapy such as carboplatin has been associated with more neutropenia and febrile neutropenia. Infection risk may therefore be higher.
What this interaction means in plain words
Carboplatin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on neutrophil counts when trastuzumab is added to myelosuppressive chemotherapy.
What to do
Monitor complete blood counts and signs of infection. Use growth factor support or dose delays per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carboplatin
Other interactions of Trastuzumab
Frequently asked questions
Can I take Carboplatin with Trastuzumab?
MediHelp rates the interaction as moderate. Carboplatin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab combined with myelosuppressive chemotherapy such as carboplatin has been associated with more neutropenia and febrile neutropenia. Infection risk may therefore be higher.
How serious is the interaction between Carboplatin and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection. Use growth factor support or dose delays per protocol.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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