Drug interactions
Carboprost tromethamine + Oxytocin
Severity: Major
Carboprost tromethamine and Oxytocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carboprost and oxytocin both stimulate uterine contraction, and used together their effects are potentiated. This is sometimes done deliberately for postpartum hemorrhage, but it raises the risk of uterine hypertonus and, before delivery, uterine rupture.
What this interaction means in plain words
Carboprost tromethamine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive uterotonic effect through prostaglandin F2-alpha receptor and oxytocin receptor stimulation.
What to do
Use together only under obstetric supervision with continuous monitoring of uterine tone and fetal status where relevant. Avoid in the antepartum setting unless clearly indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxytocin
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
- Oxytocin + Phenylephrine Major
Frequently asked questions
Can I take Carboprost tromethamine with Oxytocin?
MediHelp rates the interaction as major. Carboprost tromethamine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carboprost and oxytocin both stimulate uterine contraction, and used together their effects are potentiated. This is sometimes done deliberately for postpartum hemorrhage, but it raises the risk of uterine hypertonus and, before delivery, uterine rupture.
How serious is the interaction between Carboprost tromethamine and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only under obstetric supervision with continuous monitoring of uterine tone and fetal status where relevant. Avoid in the antepartum setting unless clearly indicated.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Dinoprostone, Ephedrine, Fexinidazole. The full list is on the Oxytocin page.
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