Drug interactions
Givinostat + Oxytocin
Severity: Major
Givinostat and Oxytocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval and oxytocin has been associated with QT prolongation, so the effects may add together. This raises the risk of ventricular arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Givinostat and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Oxytocin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if possible; otherwise obtain ECGs at initiation and during co-use, correct electrolytes, and withhold the offending drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxytocin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Oxytocin?
MediHelp rates the interaction as major. Givinostat and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval and oxytocin has been associated with QT prolongation, so the effects may add together. This raises the risk of ventricular arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Givinostat and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECGs at initiation and during co-use, correct electrolytes, and withhold the offending drug if QTc becomes markedly prolonged.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Dinoprostone, Ephedrine. The full list is on the Oxytocin page.
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