Drug interactions
Carisoprodol + Codeine
Severity: Major
Carisoprodol and Codeine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so combined use can cause marked sedation and respiratory depression. Carisoprodol is metabolized to meprobamate, which adds to the sedative load.
What this interaction means in plain words
Carisoprodol and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid combining where possible; if necessary, use the lowest doses for a short time and monitor sedation and breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Codeine?
MediHelp rates the interaction as major. Carisoprodol and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, so combined use can cause marked sedation and respiratory depression. Carisoprodol is metabolized to meprobamate, which adds to the sedative load.
How serious is the interaction between Carisoprodol and Codeine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary, use the lowest doses for a short time and monitor sedation and breathing.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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