Drug interactions
Carisoprodol + Cyproheptadine
Severity: Moderate
Carisoprodol and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can cause significant drowsiness, dizziness and impaired coordination, raising the risk of falls and accidents.
What this interaction means in plain words
Carisoprodol and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Cyproheptadine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and carisoprodol GABA-A related effects.
What to do
Use the lowest effective doses for the shortest time, avoid alcohol, and counsel against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Cyproheptadine?
MediHelp rates the interaction as moderate. Carisoprodol and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can cause significant drowsiness, dizziness and impaired coordination, raising the risk of falls and accidents.
How serious is the interaction between Carisoprodol and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time, avoid alcohol, and counsel against driving until the response is known.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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