Drug interactions
Carisoprodol + Methadone
Severity: Major
Carisoprodol and Methadone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and combining a muscle relaxant with an opioid increases the risk of profound sedation, respiratory depression and overdose. Carisoprodol is metabolized to meprobamate, which has barbiturate-like effects.
What this interaction means in plain words
Carisoprodol and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination where possible; if it is necessary, use the lowest doses for the shortest time. Monitor sedation and respiratory function and counsel patient and family about warning signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Methadone?
MediHelp rates the interaction as major. Carisoprodol and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, and combining a muscle relaxant with an opioid increases the risk of profound sedation, respiratory depression and overdose. Carisoprodol is metabolized to meprobamate, which has barbiturate-like effects.
How serious is the interaction between Carisoprodol and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, use the lowest doses for the shortest time. Monitor sedation and respiratory function and counsel patient and family about warning signs.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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