Drug interactions
Carisoprodol + Oxazepam
Severity: Major
Carisoprodol and Oxazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carisoprodol adds to benzodiazepine CNS and respiratory depression, and its metabolite meprobamate has its own sedative-anxiolytic activity. The combination increases risk of oversedation, falls and overdose.
What this interaction means in plain words
Carisoprodol and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid if possible; otherwise use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and advise against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carisoprodol
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Carisoprodol with Oxazepam?
MediHelp rates the interaction as major. Carisoprodol and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carisoprodol adds to benzodiazepine CNS and respiratory depression, and its metabolite meprobamate has its own sedative-anxiolytic activity. The combination increases risk of oversedation, falls and overdose.
How serious is the interaction between Carisoprodol and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and advise against alcohol and driving.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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