Drug interactions
Carmustine + Ifosfamide
Severity: Moderate
Carmustine and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, so combining them can produce deeper and more prolonged cytopenias. Carmustine also causes delayed marrow toxicity and pulmonary toxicity, which may complicate recovery.
What this interaction means in plain words
Carmustine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carmustine belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Additive bone marrow suppression from two alkylating agents.
What to do
Monitor complete blood counts frequently, including after nadir, and adjust doses or delay cycles for cytopenias. Provide supportive care such as growth factors as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Carmustine
- Carmustine + Pentostatin Contraindicated
- Carmustine + Chlorambucil Major
- Carmustine + Cimetidine Major
- Carmustine + Cyclophosphamide Major
- Carmustine + Dacarbazine Major
- Carmustine + Fingolimod Major
Frequently asked questions
Can I take Carmustine with Ifosfamide?
MediHelp rates the interaction as moderate. Carmustine and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, so combining them can produce deeper and more prolonged cytopenias. Carmustine also causes delayed marrow toxicity and pulmonary toxicity, which may complicate recovery.
How serious is the interaction between Carmustine and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, including after nadir, and adjust doses or delay cycles for cytopenias. Provide supportive care such as growth factors as indicated.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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