Drug interactions
Carmustine + Trastuzumab
Severity: Moderate
Carmustine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carmustine causes delayed, prolonged bone marrow suppression, and trastuzumab combined with cytotoxic therapy has been linked to more neutropenia and febrile neutropenia. The combination may raise the risk of infection.
What this interaction means in plain words
Carmustine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carmustine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression, driven mainly by the alkylating effect of carmustine on bone marrow.
What to do
Monitor complete blood counts, including nadir counts over several weeks, and watch for infection. Adjust carmustine dosing or give growth factor support if marked cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Carmustine
- Carmustine + Pentostatin Contraindicated
- Carmustine + Chlorambucil Major
- Carmustine + Cimetidine Major
- Carmustine + Cyclophosphamide Major
- Carmustine + Dacarbazine Major
- Carmustine + Fingolimod Major
Frequently asked questions
Can I take Carmustine with Trastuzumab?
MediHelp rates the interaction as moderate. Carmustine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carmustine causes delayed, prolonged bone marrow suppression, and trastuzumab combined with cytotoxic therapy has been linked to more neutropenia and febrile neutropenia. The combination may raise the risk of infection.
How serious is the interaction between Carmustine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts, including nadir counts over several weeks, and watch for infection. Adjust carmustine dosing or give growth factor support if marked cytopenias occur.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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