Drug interactions
Carvedilol + Desvenlafaxine
Severity: Minor
Carvedilol and Desvenlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, and at high doses it might raise carvedilol exposure slightly. Clinical significance is likely small.
What this interaction means in plain words
Carvedilol and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Desvenlafaxine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6-mediated carvedilol metabolism.
What to do
Monitor heart rate and blood pressure when high desvenlafaxine doses are used, and lower the carvedilol dose if bradycardia or dizziness develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Carvedilol with Desvenlafaxine?
MediHelp rates the interaction as minor. Carvedilol and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, and at high doses it might raise carvedilol exposure slightly. Clinical significance is likely small.
How serious is the interaction between Carvedilol and Desvenlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when high desvenlafaxine doses are used, and lower the carvedilol dose if bradycardia or dizziness develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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