Drug interactions
Carvedilol + Eprosartan
Severity: Moderate
Carvedilol and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so the combination produces additive hypotension and is often used deliberately in hypertension or heart failure. Angiotensin receptor blockade can raise potassium and impair renal function, and beta-blockers may modestly contribute to hyperkalaemia.
What this interaction means in plain words
Carvedilol and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, and reduced aldosterone-mediated potassium excretion with eprosartan, with a minor beta-blocker effect on cellular potassium uptake.
What to do
Monitor blood pressure, serum potassium and creatinine after initiation and dose changes. Counsel on dizziness and avoid unnecessary potassium supplements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Carvedilol with Eprosartan?
MediHelp rates the interaction as moderate. Carvedilol and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so the combination produces additive hypotension and is often used deliberately in hypertension or heart failure. Angiotensin receptor blockade can raise potassium and impair renal function, and beta-blockers may modestly contribute to hyperkalaemia.
How serious is the interaction between Carvedilol and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after initiation and dose changes. Counsel on dizziness and avoid unnecessary potassium supplements.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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