Drug interactions
Carvedilol + Flurbiprofen
Severity: Moderate
Carvedilol and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of beta-blockers, especially with sustained use. Blood pressure may rise and need therapy adjustment.
What this interaction means in plain words
Carvedilol and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention and counteracts blood pressure reduction.
What to do
Monitor blood pressure and heart failure symptoms when starting or stopping the NSAID and adjust therapy if needed. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Flurbiprofen?
MediHelp rates the interaction as moderate. Carvedilol and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of beta-blockers, especially with sustained use. Blood pressure may rise and need therapy adjustment.
How serious is the interaction between Carvedilol and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart failure symptoms when starting or stopping the NSAID and adjust therapy if needed. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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