Drug interactions
Carvedilol + Fluticasone-salmeterol
Severity: Major
Carvedilol and Fluticasone-salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a non-selective beta-blocker that directly opposes salmeterol and can provoke bronchospasm in patients with asthma or COPD, reducing the benefit of the inhaler.
What this interaction means in plain words
Carvedilol and Fluticasone-salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carvedilol belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Non-selective beta-1/beta-2 blockade antagonizes beta-2 agonist bronchodilation.
What to do
Avoid in asthma; in COPD prefer a cardioselective beta-blocker. If unavoidable, monitor respiratory status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Fluticasone-salmeterol?
MediHelp rates the interaction as major. Carvedilol and Fluticasone-salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a non-selective beta-blocker that directly opposes salmeterol and can provoke bronchospasm in patients with asthma or COPD, reducing the benefit of the inhaler.
How serious is the interaction between Carvedilol and Fluticasone-salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in asthma; in COPD prefer a cardioselective beta-blocker. If unavoidable, monitor respiratory status closely.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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