Drug interactions
Carvedilol + Hydralazine
Severity: Moderate
Carvedilol and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure by different mechanisms, so the combination gives additive hypotension. The pairing is clinically useful, and carvedilol can blunt the reflex tachycardia produced by hydralazine.
What this interaction means in plain words
Carvedilol and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Hydralazine belongs to Cardiovascular.
Why it happens
Additive vasodilation from direct arteriolar relaxation and alpha-1 blockade, with beta-blockade limiting reflex tachycardia.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Titrate doses gradually and reduce if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Carvedilol with Hydralazine?
MediHelp rates the interaction as moderate. Carvedilol and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure by different mechanisms, so the combination gives additive hypotension. The pairing is clinically useful, and carvedilol can blunt the reflex tachycardia produced by hydralazine.
How serious is the interaction between Carvedilol and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Titrate doses gradually and reduce if hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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