Drug interactions
Carvedilol + Hydrochlorothiazide-valsartan
Severity: Minor
Carvedilol and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol and valsartan with hydrochlorothiazide have additive blood pressure lowering effects, and orthostatic hypotension or bradycardia can occur. Potassium effects are small. Valsartan should not be used in pregnancy.
What this interaction means in plain words
Carvedilol and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from alpha/beta blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure, heart rate and potassium and counsel about postural dizziness, especially at initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Carvedilol and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol and valsartan with hydrochlorothiazide have additive blood pressure lowering effects, and orthostatic hypotension or bradycardia can occur. Potassium effects are small. Valsartan should not be used in pregnancy.
How serious is the interaction between Carvedilol and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium and counsel about postural dizziness, especially at initiation.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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