Drug interactions
Carvedilol + Ipratropium-salbutamol
Severity: Major
Carvedilol and Ipratropium-salbutamol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a non-selective beta-blocker that blocks beta-2 receptors and can antagonise salbutamol's bronchodilation. In patients with asthma or COPD it may provoke bronchospasm and make rescue inhalers less effective. Carvedilol is generally poorly suited to patients with reactive airways disease.
What this interaction means in plain words
Carvedilol and Ipratropium-salbutamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carvedilol belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors in the airways by a non-selective beta-blocker.
What to do
Avoid carvedilol in patients with asthma, and use a cardioselective beta-blocker if one is needed in COPD. If the combination cannot be avoided, monitor respiratory function closely, and higher salbutamol doses or alternative bronchodilators may be needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Ipratropium-salbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Ipratropium-salbutamol?
MediHelp rates the interaction as major. Carvedilol and Ipratropium-salbutamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a non-selective beta-blocker that blocks beta-2 receptors and can antagonise salbutamol's bronchodilation. In patients with asthma or COPD it may provoke bronchospasm and make rescue inhalers less effective. Carvedilol is generally poorly suited to patients with reactive airways disease.
How serious is the interaction between Carvedilol and Ipratropium-salbutamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid carvedilol in patients with asthma, and use a cardioselective beta-blocker if one is needed in COPD. If the combination cannot be avoided, monitor respiratory function closely, and higher salbutamol doses or alternative bronchodilators may be needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Droperidol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
