Drug interactions
Carvedilol + Istradefylline
Severity: Moderate
Carvedilol and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as carvedilol. This could enhance beta-blocking effects, including bradycardia and hypotension.
What this interaction means in plain words
Carvedilol and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits P-gp efflux of carvedilol, increasing its absorption.
What to do
Monitor heart rate and blood pressure when istradefylline is started or when its dose is raised. Reduce the carvedilol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Istradefylline
Frequently asked questions
Can I take Carvedilol with Istradefylline?
MediHelp rates the interaction as moderate. Carvedilol and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as carvedilol. This could enhance beta-blocking effects, including bradycardia and hypotension.
How serious is the interaction between Carvedilol and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when istradefylline is started or when its dose is raised. Reduce the carvedilol dose if excessive beta-blockade occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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