Drug interactions
Carvedilol + Ivosidenib
Severity: Minor
Carvedilol and Ivosidenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP enzymes and may reduce carvedilol exposure, which could weaken blood pressure or heart rate control. The effect is likely modest, as CYP2C9 is a minor route for carvedilol.
What this interaction means in plain words
Carvedilol and Ivosidenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Enzyme induction by ivosidenib increasing metabolism of carvedilol.
What to do
Monitor blood pressure and heart rate and increase the carvedilol dose if effect is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Carvedilol with Ivosidenib?
MediHelp rates the interaction as minor. Carvedilol and Ivosidenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces CYP enzymes and may reduce carvedilol exposure, which could weaken blood pressure or heart rate control. The effect is likely modest, as CYP2C9 is a minor route for carvedilol.
How serious is the interaction between Carvedilol and Ivosidenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and increase the carvedilol dose if effect is reduced.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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