Drug interactions
Carvedilol + Ketoconazole
Severity: Minor
Carvedilol and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly raise carvedilol levels, with possible increased beta-blocking and vasodilating effects such as bradycardia and hypotension. The clinical effect is generally limited.
What this interaction means in plain words
Carvedilol and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole may inhibit CYP2C9 and P-glycoprotein, which contribute to carvedilol clearance.
What to do
Monitor heart rate and blood pressure when starting or stopping ketoconazole. Adjust the carvedilol dose only if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Ketoconazole?
MediHelp rates the interaction as minor. Carvedilol and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may modestly raise carvedilol levels, with possible increased beta-blocking and vasodilating effects such as bradycardia and hypotension. The clinical effect is generally limited.
How serious is the interaction between Carvedilol and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping ketoconazole. Adjust the carvedilol dose only if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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