Drug interactions
Carvedilol + Meclofenamic acid
Severity: Moderate
Carvedilol and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use can diminish the antihypertensive effect of carvedilol. Blood pressure may rise over time, and fluid retention can aggravate heart failure.
What this interaction means in plain words
Carvedilol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduced vasodilation, opposing the beta-blocker.
What to do
Monitor blood pressure, weight and signs of fluid overload, and keep NSAID use as short and low-dose as possible. Use an alternative analgesic in patients with heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Meclofenamic acid?
MediHelp rates the interaction as moderate. Carvedilol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use can diminish the antihypertensive effect of carvedilol. Blood pressure may rise over time, and fluid retention can aggravate heart failure.
How serious is the interaction between Carvedilol and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight and signs of fluid overload, and keep NSAID use as short and low-dose as possible. Use an alternative analgesic in patients with heart failure.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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