Drug interactions
Carvedilol + Nilotinib
Severity: Moderate
Carvedilol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits several CYP enzymes including CYP2D6 and CYP2C9 and may increase carvedilol concentrations. Nilotinib also prolongs the QT interval and can cause bradycardia, so a heart-rate-lowering beta-blocker adds to the cardiac monitoring burden.
What this interaction means in plain words
Carvedilol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP2D6 and CYP2C9, reducing carvedilol metabolism, with additive bradycardic effects.
What to do
Monitor heart rate, blood pressure and ECG including QT interval while on both drugs. Lower the carvedilol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Carvedilol with Nilotinib?
MediHelp rates the interaction as moderate. Carvedilol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits several CYP enzymes including CYP2D6 and CYP2C9 and may increase carvedilol concentrations. Nilotinib also prolongs the QT interval and can cause bradycardia, so a heart-rate-lowering beta-blocker adds to the cardiac monitoring burden.
How serious is the interaction between Carvedilol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG including QT interval while on both drugs. Lower the carvedilol dose if bradycardia or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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