Drug interactions
Carvedilol + Paroxetine
Severity: Moderate
Carvedilol and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a potent CYP2D6 inhibitor and increases carvedilol exposure. This may cause greater bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Paroxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated carvedilol metabolism by paroxetine.
What to do
Monitor heart rate and blood pressure when starting or stopping paroxetine, and lower the carvedilol dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Carvedilol with Paroxetine?
MediHelp rates the interaction as moderate. Carvedilol and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine is a potent CYP2D6 inhibitor and increases carvedilol exposure. This may cause greater bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping paroxetine, and lower the carvedilol dose if symptomatic.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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