Drug interactions
Carvedilol + Rifabutin
Severity: Moderate
Carvedilol and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces hepatic drug-metabolizing enzymes and may lower carvedilol plasma concentrations, as seen with rifampicin. The result could be reduced blood pressure and heart rate control or reduced benefit in heart failure, though rifabutin is a weaker inducer than rifampicin.
What this interaction means in plain words
Carvedilol and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP enzymes and P-glycoprotein by rifabutin increases carvedilol clearance.
What to do
Monitor blood pressure and heart rate during and after rifabutin therapy. Increase the carvedilol dose if response is inadequate, and reduce it again if rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Carvedilol with Rifabutin?
MediHelp rates the interaction as moderate. Carvedilol and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces hepatic drug-metabolizing enzymes and may lower carvedilol plasma concentrations, as seen with rifampicin. The result could be reduced blood pressure and heart rate control or reduced benefit in heart failure, though rifabutin is a weaker inducer than rifampicin.
How serious is the interaction between Carvedilol and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during and after rifabutin therapy. Increase the carvedilol dose if response is inadequate, and reduce it again if rifabutin is stopped.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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