Drug interactions
Carvedilol + Sacubitril-valsartan
Severity: Moderate
Carvedilol and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are routinely used together in heart failure and they lower blood pressure additively. Hypotension, dizziness and bradycardia-related symptoms may occur especially during initiation or dose titration. Beta-blockers can also modestly raise potassium.
What this interaction means in plain words
Carvedilol and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive vasodilatory and negative chronotropic pharmacodynamic effects; beta-blockade slightly impairs cellular potassium uptake.
What to do
Monitor blood pressure, heart rate and serum potassium during initiation and titration. Stagger dose increases of the two agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Carvedilol and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are routinely used together in heart failure and they lower blood pressure additively. Hypotension, dizziness and bradycardia-related symptoms may occur especially during initiation or dose titration. Beta-blockers can also modestly raise potassium.
How serious is the interaction between Carvedilol and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium during initiation and titration. Stagger dose increases of the two agents.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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