Drug interactions
Albuterol + Labetalol
Severity: Moderate
Albuterol and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-adrenergic receptors and can reduce the bronchodilator effect of albuterol. In patients with asthma or COPD, nonselective beta-blockade can also provoke bronchospasm.
What this interaction means in plain words
Albuterol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Avoid labetalol in patients with significant reactive airway disease where possible, or choose a cardioselective agent. If used together, monitor respiratory status and response to albuterol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Albuterol with Labetalol?
MediHelp rates the interaction as moderate. Albuterol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks beta-adrenergic receptors and can reduce the bronchodilator effect of albuterol. In patients with asthma or COPD, nonselective beta-blockade can also provoke bronchospasm.
How serious is the interaction between Albuterol and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid labetalol in patients with significant reactive airway disease where possible, or choose a cardioselective agent. If used together, monitor respiratory status and response to albuterol.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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