Drug interactions
Carvedilol + Sotorasib
Severity: Moderate
Carvedilol and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-glycoprotein inhibitor and may raise carvedilol exposure. This could increase bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-glycoprotein, reducing efflux of the substrate carvedilol and increasing its systemic exposure.
What to do
Monitor heart rate and blood pressure after sotorasib is started. Reduce the carvedilol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Carvedilol with Sotorasib?
MediHelp rates the interaction as moderate. Carvedilol and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak P-glycoprotein inhibitor and may raise carvedilol exposure. This could increase bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after sotorasib is started. Reduce the carvedilol dose if bradycardia or hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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