Drug interactions
Carvedilol + Timolol
Severity: Moderate
Carvedilol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block beta receptors, and systemic timolol, including absorption from eye drops, adds to carvedilol's effects. The combination raises the risk of bradycardia, hypotension, and AV block.
What this interaction means in plain words
Carvedilol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic blockade, with added alpha-1 blockade from carvedilol.
What to do
Avoid oral duplication of beta-blockers. If timolol eye drops are used, monitor heart rate and blood pressure, or consider a non-beta-blocker glaucoma agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Timolol?
MediHelp rates the interaction as moderate. Carvedilol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block beta receptors, and systemic timolol, including absorption from eye drops, adds to carvedilol's effects. The combination raises the risk of bradycardia, hypotension, and AV block.
How serious is the interaction between Carvedilol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral duplication of beta-blockers. If timolol eye drops are used, monitor heart rate and blood pressure, or consider a non-beta-blocker glaucoma agent.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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