Drug interactions
Cefadroxil + Dexamethasone-tobramycin
Severity: Minor
Cefadroxil and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent cephalosporin and aminoglycoside therapy has been associated with additive kidney injury, mainly in at-risk patients. Cefadroxil is an oral agent with little nephrotoxic potential, so the risk is small.
What this interaction means in plain words
Cefadroxil and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; mechanism not firmly established for this cephalosporin.
What to do
Monitor renal function and tobramycin levels as usual during aminoglycoside therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Cefadroxil and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent cephalosporin and aminoglycoside therapy has been associated with additive kidney injury, mainly in at-risk patients. Cefadroxil is an oral agent with little nephrotoxic potential, so the risk is small.
How serious is the interaction between Cefadroxil and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tobramycin levels as usual during aminoglycoside therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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