Drug interactions
Cefadroxil + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Minor
Cefadroxil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics are often cited as potentially reducing combined oral contraceptive efficacy through effects on gut flora. Apart from rifamycins, controlled studies have not shown a meaningful fall in hormone levels or ovulation suppression. Risk with cefadroxil is regarded as very low.
What this interaction means in plain words
Cefadroxil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed disruption of enterohepatic recycling of ethinylestradiol via altered gut bacteria, not well supported for cephalosporins.
What to do
No additional contraception is routinely required. Advise backup contraception if vomiting or severe diarrhea occurs during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as minor. Cefadroxil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics are often cited as potentially reducing combined oral contraceptive efficacy through effects on gut flora. Apart from rifamycins, controlled studies have not shown a meaningful fall in hormone levels or ovulation suppression. Risk with cefadroxil is regarded as very low.
How serious is the interaction between Cefadroxil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is routinely required. Advise backup contraception if vomiting or severe diarrhea occurs during treatment.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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