Drug interactions
Cefadroxil + Mycophenolate
Severity: Moderate
Cefadroxil and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some antibiotics, including cephalosporins, have been associated with lower mycophenolic acid exposure, probably by reducing gut bacteria that deconjugate the glucuronide and allow its reabsorption. The legacy renal competition explanation is not well supported. Reduced exposure could weaken immunosuppression.
What this interaction means in plain words
Cefadroxil and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable reduction of enterohepatic recirculation of mycophenolic acid glucuronide due to gut flora changes.
What to do
Watch for signs of graft rejection or reduced immunosuppression during and after the antibiotic course. Consider mycophenolic acid level monitoring where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Mycophenolate?
MediHelp rates the interaction as moderate. Cefadroxil and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Some antibiotics, including cephalosporins, have been associated with lower mycophenolic acid exposure, probably by reducing gut bacteria that deconjugate the glucuronide and allow its reabsorption. The legacy renal competition explanation is not well supported. Reduced exposure could weaken immunosuppression.
How serious is the interaction between Cefadroxil and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of graft rejection or reduced immunosuppression during and after the antibiotic course. Consider mycophenolic acid level monitoring where available.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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