Drug interactions
Cefamandole + Enoxaparin
Severity: Moderate
Cefamandole and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole has an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and platelet dysfunction, which may add to the bleeding tendency of enoxaparin. The risk is greater in malnourished, elderly or renally impaired patients.
What this interaction means in plain words
Cefamandole and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment through vitamin K-dependent clotting factor reduction and platelet dysfunction from the cephalosporin side chain.
What to do
Monitor for bleeding and check PT/INR if therapy is prolonged. Consider vitamin K supplementation in at-risk patients or choose a cephalosporin without this side chain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefamandole and Enoxaparin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Cefamandole with Enoxaparin?
MediHelp rates the interaction as moderate. Cefamandole and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefamandole has an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and platelet dysfunction, which may add to the bleeding tendency of enoxaparin. The risk is greater in malnourished, elderly or renally impaired patients.
How serious is the interaction between Cefamandole and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check PT/INR if therapy is prolonged. Consider vitamin K supplementation in at-risk patients or choose a cephalosporin without this side chain.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
