Drug interactions
Cefamandole + Ibuprofen
Severity: Minor
Cefamandole and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are acidic compounds partly eliminated by renal tubular secretion, so competition could modestly raise ibuprofen levels. Cefamandole also has a methylthiotetrazole side chain linked to coagulation abnormalities, which could add to NSAID bleeding risk.
What this interaction means in plain words
Cefamandole and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal organic anion tubular secretion; cefamandole may also impair vitamin K-dependent clotting.
What to do
No routine adjustment needed; monitor for bleeding if cefamandole is given for a prolonged course or in patients with risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Cefamandole with Ibuprofen?
MediHelp rates the interaction as minor. Cefamandole and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are acidic compounds partly eliminated by renal tubular secretion, so competition could modestly raise ibuprofen levels. Cefamandole also has a methylthiotetrazole side chain linked to coagulation abnormalities, which could add to NSAID bleeding risk.
How serious is the interaction between Cefamandole and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor for bleeding if cefamandole is given for a prolonged course or in patients with risk factors.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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