Drug interactions
Cefamandole + Meclofenamic acid
Severity: Minor
Cefamandole and Meclofenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins are organic acids that are secreted by renal tubular anion transporters, as are NSAIDs. Competition could modestly raise meclofenamate exposure, but the clinical effect is small. Cefamandole also carries its own bleeding risk through vitamin K-related hypoprothrombinemia, which could add to NSAID effects on platelets and gastric mucosa.
What this interaction means in plain words
Cefamandole and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion, with additive effects on hemostasis.
What to do
No routine adjustment is needed; watch for gastrointestinal bleeding or bruising during prolonged courses. Check coagulation parameters if the patient is malnourished or has renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Cefamandole with Meclofenamic acid?
MediHelp rates the interaction as minor. Cefamandole and Meclofenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalosporins are organic acids that are secreted by renal tubular anion transporters, as are NSAIDs. Competition could modestly raise meclofenamate exposure, but the clinical effect is small. Cefamandole also carries its own bleeding risk through vitamin K-related hypoprothrombinemia, which could add to NSAID effects on platelets and gastric mucosa.
How serious is the interaction between Cefamandole and Meclofenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for gastrointestinal bleeding or bruising during prolonged courses. Check coagulation parameters if the patient is malnourished or has renal impairment.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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