Drug interactions
Cefamandole + Tolmetin
Severity: Minor
Cefamandole and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole and tolmetin are both secreted by renal organic anion transporters, so competition could modestly raise tolmetin levels. Cefamandole can also impair coagulation, which may add to the NSAID bleeding risk.
What this interaction means in plain words
Cefamandole and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic secretion; cefamandole may also impair vitamin K-dependent clotting.
What to do
Monitor for NSAID adverse effects and bleeding signs during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Cefamandole with Tolmetin?
MediHelp rates the interaction as minor. Cefamandole and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefamandole and tolmetin are both secreted by renal organic anion transporters, so competition could modestly raise tolmetin levels. Cefamandole can also impair coagulation, which may add to the NSAID bleeding risk.
How serious is the interaction between Cefamandole and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects and bleeding signs during combined use.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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